Case Report: Identification of Two Rare Fusions, PDK1-ALK and STRN-ALK, That Coexist in a Lung Adenocarcinoma Patient and the Response to Alectinib

Several double ALK fusions coexisting in one patient have been reported.However, few studies have reported the clinical efficacy of ALK inhibitors in rare T/T House Loft Bed double ALK fusions.Here, we described a rare PDK1-ALK, STRN-ALK double-fusion variant in a patient with metastatic lung adenocarcinoma.The Eyeshadows patient responded well to alectinib (600 mg) twice daily.

This case shows a promising treatment option for patients with rare ALK double-fusion variants.